Annual report pursuant to Section 13 and 15(d)

11. STOCK-BASED COMPENSATION (Details - Option activity)

v3.7.0.1
11. STOCK-BASED COMPENSATION (Details - Option activity) - Options [Member] - USD ($)
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Share-based compensation activity      
Options outstanding, beginning balance 9,799,036 6,470,000  
Options outstanding, granted 3,220,000 3,605,000  
Options outstanding, exercised 0 0  
Options outstanding, forfeited (74,631) (262,632)  
Options outstanding, expired (103,405) (13,332)  
Options outstanding, ending balance 12,841,000 9,799,036 6,470,000
Options outstanding, exercisable 9,116,767 3,048,869  
Options outstanding, unvested 3,724,233    
Options outstanding, vested or expected to vest 12,841,000    
Weighted average exercise price, beginning balance $ 1.97 $ 2.70  
Weighted average exercise price, granted 0.36 0.71  
Weighted average exercise price, exercised  
Weighted average exercise price, forfeited 0.55 2.59  
Weighted average exercise price, expired 2.34 2.82  
Weighted average exercise price, ending balance 1.57 $ 1.97 $ 2.70
Weighted average exercise price, exercisable 1.91    
Weighted average exercise price, unvested 0.75    
Weighted average exercise price, vested or expected to vest $ 1.57    
Weighted average remaining contract term, ending term 8 years 6 months 15 days 9 years 2 months 12 days 9 years 10 months 17 days
Weighted average remaining contract term, exercisable 8 years 3 months 4 days    
Weighted average remaining contract term, unvested 9 years 2 months 19 days    
Weighted average remaining contract term, vested or expected to vest 8 years 6 months 15 days    
Aggregate intrinsic value, ending balance $ 415,135 $ 57,800  
Aggregate intrinsic value, exercisable 196,580    
Aggregate intrinsic value, unvested 218,555    
Aggregate intrinsic value, vested or expected to vest $ 415,135