Annual report pursuant to Section 13 and 15(d)

10. STOCK-BASED COMPENSATION (Details - Option activity)

v3.8.0.1
10. STOCK-BASED COMPENSATION (Details - Option activity) - Options [Member] - USD ($)
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Share-based compensation activity      
Options outstanding, beginning balance 12,841,000 9,799,036  
Options outstanding, granted 10,312,000 3,220,000  
Options outstanding, exercised 0 0  
Options outstanding, forfeited (6,930,976) (74,631)  
Options outstanding, expired (398,747) (103,405)  
Options outstanding, ending balance 15,823,277 12,841,000 9,799,036
Options outstanding, exercisable 12,084,662    
Options outstanding, unvested 3,738,615    
Options outstanding, vested or expected to vest 15,823,277    
Weighted average exercise price, beginning balance $ 1.57 $ 1.97  
Weighted average exercise price, granted 0.36 0.36  
Weighted average exercise price, exercised  
Weighted average exercise price, forfeited 2.37 0.55  
Weighted average exercise price, expired 0.43 2.34  
Weighted average exercise price, ending balance 0.46 $ 1.57 $ 1.97
Weighted average exercise price, exercisable 0.50    
Weighted average exercise price, unvested 0.35    
Weighted average exercise price, vested or expected to vest $ 1.57    
Weighted average remaining contract term, ending term 7 years 10 months 28 days 8 years 6 months 14 days 9 years 2 months 12 days
Weighted average remaining contract term, exercisable 7 years 8 months 23 days    
Weighted average remaining contract term, unvested 8 years 5 months 23 days    
Weighted average remaining contract term, vested or expected to vest 8 years 6 months 14 days    
Aggregate intrinsic value, ending balance $ 5,406,499 $ 415,135 $ 57,800
Aggregate intrinsic value, exercisable 2,059,545    
Aggregate intrinsic value, unvested 2,896,954    
Aggregate intrinsic value, vested or expected to vest $ 5,406,499