Exhibit 16.1

Deloitte & Touche LLP

12830 El Camino Real

Suite 600

San Diego, CA 92130

USA

Tel:+1 619 232 6500

Fax:+1 619 237 6802

www.deloitte.com

November 30, 2021

Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549-7561

Dear Sirs/Madams:

We have read Item 4.01 of CV Sciences, Inc. Form 8-K dated November 30, 2021, and we agree with the statements made therein.

Yours truly,

/s/ DELOITTE & TOUCHE LLP